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Gene Page - CG Number : CG12079
Gene Summary - CG12079:

CG12079: This gene is referred to in FlyBase by the symbol Dmel\CG12079 (FBgn0035404). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: NADH dehydrogenase activity; NADH dehydrogenase (ubiquinone) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mitochondrion. It has one annotated transcript and one annotated polypeptide. Protein features are: NADH dehydrogenase, subunit C; NADH:ubiquinone oxidoreductase, 30kDa subunit; NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.

Gene summary for CG12079 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG12079:CG12079 is not perturbed in primary screen.
CG12079 is not tested in classification assay (fluid).
CG12079 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fint1- NuCellD-(tfr) NuCirc+(tfr) NuFluct-(tfr) NuSize-(tfr) Okt+(tfr) Tint1+
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG12079.
Cell Count:
CG_NumberCategoryR1R2R3
CG12079Primary screen17985135
CG12079Secondary assay472631885
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG12079:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22199-0.842806190.0072249170.121185952-0.603058803-0.991819014-2.095995942-1.7841332-2.5468895870.0936699571.8320722961.409726095-0.162060804-0.035314601-0.0202883650.1580891281.248487750.9792453480.8026832050.6323636730.232227108-0.1607792161.027841857-0.676324082
222247-0.391170422-0.733003004-0.5965289930.655808001-2.082009339-1.686028236-1.68944424-1.768632992-2.295408949-1.361083674-1.593371160.751357403-0.815015191-1.051953494-0.897824655-2.437212542-1.770989069-1.705728413-1.787623253-2.068502668-0.0855185480.43535709-0.47459773
223370.944278096-0.4664595530.309878752.243460103-2.094840879-2.62602707-0.937692188-2.676044655-1.022146745-0.519642884-1.6657286550.092621748-2.195970298-2.70665377-0.554896942-0.489784606-0.405000548-0.550223449-0.847245512-0.9786849880.3794015541.6878285190.005312755
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG12079Slide13F0.0010.6940.7800.747
CG12079Slide13O0.0191.3151.1471.261
CG12079Slide13T0.8170.6360.4271.635
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG12079 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
oxidation-reduction processGO:0055114inferred from electronic annotation with InterPro:IPR001268, InterPro:IPR010218, InterPro:IPR020396
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
mitochondrial respiratory chain complex IGO:0005747inferred from sequence or structural similarity with EMBL:M58469
mitochondrial respiratory chain complex I
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
NADH dehydrogenase (ubiquinone) activityGO:0008137inferred from sequence or structural similarity with EMBL:M58469
NADH dehydrogenase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG12079 in FlyBase
FLIGHTClick here to see CG12079 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG12079 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG12079
Entrez GeneEntrez Gene page for CG12079
UniprotUniprot page for CG12079

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)