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Gene Page - CG Number : CG12086
Gene Summary - CG12086:

CG12086: The gene cueball is referred to in FlyBase by the symbol Dmel\cue (CG12086, FBgn0011204). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: low-density lipoprotein receptor activity. There is experimental evidence that it is involved in the biological process: primary spermatocyte growth. 14 alleles are reported. The phenotypes of these alleles are annotated with: ovary; testis; spermatocyte; primary spermatocyte cyst. It has one annotated transcript and one annotated polypeptide. Protein features are: EGF-like, conserved site; Epidermal growth factor-like domain; LDLR class B repeat; Six-bladed beta-propeller, TolB-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG12086 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG12086:CG12086 is perturbed in following parameters in primary screen: Rto1
CG12086 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG12086.
Cell Count:
CG_NumberCategoryR1R2R3
CG12086Primary screen209208144
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG12086:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
221104-0.332751551.0956658740.7251533180.4191598310.4933759450.8191730911.4722411670.460939620.6657607850.4750782290.5212843760.5714969850.0858983130.690611059-0.0773505360.4667355960.5025475350.4920893870.7056878310.939705846-0.7156033421.2239168761.253421018
2222420.436119936-0.1433271830.325009484-0.001171670.3140585341.6149629742.2983213641.0243206251.1112954070.3925490350.7760770823.2007243760.9083250731.089891969-0.592351711.4182317390.7777914882.5800059451.1218016581.1733744941.1567338151.0273689181.237129025
22332-0.510985021-0.821943042-0.8127749150.936819194-0.199149116-0.464697903-0.437326078-0.508367587-0.586099086-0.13293645-0.3726559723.1221907060.3166762880.7358139730.1113646080.138210186-0.086015872-0.147872233-0.438020014-0.64023942-0.830888386-0.388449864-0.639486674
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG12086 is not tested in classification assay
Integrated Annotations for CG12086 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
primary spermatocyte growthGO:0007285inferred from mutant phenotype
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
low-density lipoprotein receptor activityGO:0005041inferred from sequence or structural similarity with UniProtKB:P98157
Other annotations
DatabaseLink
FlyBaseClick here to see CG12086 in FlyBase
FLIGHTClick here to see CG12086 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG12086 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG12086
Entrez GeneEntrez Gene page for CG12086
UniprotUniprot page for CG12086

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)